Methylated seed oils (MSO) are gaining importance as co-solvents/adjuvants in agricultural formulations, because they can enhance the biological efficacy of the increasingly complex lower soluble new active ingredients. The skin-sensitizing results reported in the literature for some unsaturated carbon-carbon double-bond lipids (MSO constituents) suggested positive results, more frequently in the murine local lymph node assay (LLNA) compared with those in the guinea pig maximization test (GPMT) and/or in human subjects. As the LLNA is one of the gold-standard methods for regulatory registration purposes, it is relevant to elucidate factors leading to positive skin sensitization results of MSO components. In the current study, chemical structure-skin sensitization relationships which can rationalize patterns of varying sensitization potential among the carbon chain length and degree of unsaturation were investigated for a series of individual fatty acids and their corresponding methylated esters using the in-vitro KeratinoSens™ assay. Results show that the degree of unsaturation increased the skin sensitization potential and suggested an inverse relationship with increasing carbon chain length.

Effect of carbon chain length and degree of unsaturation on skin sensitization potential of fatty acids and their corresponding methylated esters

256th National Meeting (2018)

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