Insecticides are the cornerstone of insect transmitted disease control and largely responsible for the reduction in malaria transmission by Anopheline mosquitoes in Africa  this century.  Transcriptional profiling, population genomic, biochemical and transgenic approaches have been applied to determine the causes of insecticide in malaria and other tropical disease vectors.  Great strides have been made in identifying target genes and networks associated with insecticide metabolism in mosquitoes.   This is feeding the development of new vector control tools to monitor and predict insecticide resistance liabilities.   Most recently, results from the Ag1000g project highlight extreme genetic diversity in <i>An. gambiae</i> (a variant allele every 2.2 bases).  This focusses our attention on the production of tools capable of functional differentiation of resistance.  This presentation explores recent developments and their potential impact on tropical disease control.  <br/>

Insecticide resistance and management of malaria vectors

256th National Meeting (2018)

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