In order to apply biosensors into point-of-care diagnostics and continuous health monitoring systems, there is a need to push the limit on their performance metrics such as limit-of-detection, specificity, and speed while meeting design requirements in terms of portability, multiplexing, cost, and ease of use. The structural parameters of materials used in biosensors play a critical in meeting the performance metrics and design requirements of these systems.<br/>In this work, we have developed a versatile fabrication toolbox for creating three dimensional anti-fouling surfaces. Self-assembly, electrochemical deposition, and polymer-induced wrinkling are combined to create surfaces that are tunable in terms of conductivity, minimum feature size, and surface energy. These surfaces are then combined with biorecognition elements to create high sensitivity electrochemical biosensors that are used in detecting small molecules, proteins, and nucleic acids.<br/>Using the surfaces developed here, we demonstrate the role of structural tunability of materials in enhancing the sensitivity and lowering the background signal of biosensors. We further demonstrate the clinical application of these biosensors by using them in the diagnosis of endometriosis in patient samples. We observe excellent correlation between the results obtained here and those obtained using conventional assays for protein analysis.<br/>

Rapid prototyping of bioinspired materials for biosensing

256th National Meeting (2018)

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