Medicinally relevant natural products are found in a variety of therapeutic areas including oncology (Taxol™) and infectious diseases (artemisinin). Despite possessing intriguing biological properties, the widespread utilization of natural products as potential drug candidates is hampered by several development issues, namely low isolation yields and nonrenewable natural resources. The Baran Lab is interested in developing strategies to access useful quantities of densely oxidized natural products, exemplified by thapsigargin and tagetitoxin. The two-phase terpene synthesis logic enabled the successful total synthesis thapsigargin. Currently, a scalable route is under development to access tagetitoxin. Specifically, these routes were designed to bolster the feasibility pertaining to the scalable access of the parent natural products and the production of medicinally relevant analogues.<br/>

Total syntheses of highly oxidized bioactive natural products

256th National Meeting (2018)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.