Many cancers are hallmarked by the presence of tumor cells in blood, for example circulating tumor cells in metastatic disease, or leukemic blasts in various blood cancers. There is a need in innovative tools for detection and eradication of these cells. We developed lipid-antibody based nano-assemblies for painting of red blood cells (erythrocytes) for cancer therapy. Using lipid antibody modified erythrocytes, we demonstrated targeting of various cancer cells and leukocytes in vivo. Furthermore, we demonstrated long-circulating properties of lipid-antibody modified erythrocytes. We will further describe the synthesis of novel amino indocyanine C18 antibody conjugates for advanced and more efficient cell painting. Anti-CD45 and anti-CD20 painted erythrocytes injected into mice were able to efficiently deplete leukemic cells in blood and peripheral organs, including bone marrow. Lipid antibody nano-assemblies are a promising tool for cell-based therapies.   <br/>

Engineered lipid-antibody based nano-assemblies for painting and surface modifications of red blood cells for therapy of blood borne cancers

256th National Meeting (2018)

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