Gold nanoparticles (AuNPs) are promising as delivery agents, but the influence of key design parameters such as size and shape of the particle core and ligand density is incomplete. This talk will describe a side-by-side comparison of three different AuNP cores (13-nm spheres, 50-nm spheres, and 40-nm stars) with the same oligonucleotide surface density applied to two different systems. First, we will discuss how different NP cores affect the intracellular distribution and delivery of siRNA. Second, we will examine how different NP cores with CpG ligands affect immunostimulatory activity. Finally, we will describe the promise and challenges of designing a nanoparticle platform for delivering specific ligands in different cellular systems.

Designer nanoparticles for intracellular targeting and delivery

256th National Meeting (2018)

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