2-amino-α-carboline is a heterocyclic aromatic amine that is a mutagen and carcinogen capable of DNA damage and altering genetic information. This carcinogen is formed as a by-product of food during high-temperature treatment of food and also found in tobacco smoke. The metabolite of these mutagens covalently bind to the C8-position on guanine in DNA. The resulting DNA lesions can typically be repaired, but if they are unrepaired, mutations form. We have synthesized derivatives of 2-amino-α-carboline by conventional heterocycle chemistry and C-H activation methods to be used for the formation of DNA adducts. The study of these adducts will aid in understanding the mechanism of disease state’s proliferation.

Synthesis of mutagenic DNA adducts derived from 2-amino-α-carboline derivatives

256th National Meeting (2018)

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