The ever-increasing requirement for determination of contaminants along with studies of comprehensive metabolite networks in complex samples parallel advancements in solid phase microextraction (SPME) technique.  The availability of state-of-the-art analytical instrumentation offering higher sensitivity and specificity has contributed to an increased range of applications covered by the SPME technique.  The presentation will summarise the most underlying aspects in SPME development addressing some of the challenges encountered in the analysis of complex samples, with particular emphasis placed on direct extraction and rapid screening.  In addition, the development of new morphologies or extracting materials and novel sampling configurations as well as approaches compatible with high throughput lab and/or on-site determinations will be outlined.  The recent development of matrix compatible SPME coating lead to interesting features experienced during extraction, some of them not anticipated.  They are not limited to elimination of fouling and saturation effects during direct SPME of complex samples, but also balance coverage property, enabling “via free form” clean extraction of small molecules widely varying in physical properties leading to some interesting applications.  For example, on-site sampling, in-vivo metabolomics, and rapid screening via direct coupling of sample preparation to mass spectrometry were facilitated by this development.  To serve as a guide to potential opportunities for continued innovation in SPME food applications, special emphasis will be placed on the evolution of on-site and in vivo SPME techniques and their feasibility for both targeted determination of organic pollutants and biologically active compounds, as well as for global metabolite analysis.

New developments in SPME

256th National Meeting (2018)

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