Alicyclic amines are one of the most common structural motifs present in FDA approved drugs, making them attractive substrates for late-stage functionalization. This presentation will describe the development of methods that exchange hydrogen for deuterium at the C-4 position of these substrates. Both mechanistic and synthetic aspects of this H/D exchange process will be presented. <br/>

Palladium(II)-catalyzed H/D exchange reactions of alicyclic amines

256th National Meeting (2018)

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