The dehydrogenative cross-coupling of aromatic moieties provides an innovative access to molecular building blocks which usually afford multi-step sequences. The direct use of electricity instead of stoichiometric reagents represents an outstandingly green aspect of bond formation. In order to achieve selectivity in cross-coupling reaction the use of solvent control is an efficient parameter. Best results are obtained with fluorinated alcohols, such as 1,1,1,3,3,3-hexafluoroisopropanol (HFIP). The fields of applications are cross-coupling reactions of phenol-phenol, phenol-arene, phenol-heterocycles, aniline-aniline, aniline-phenol, etc. In particular, when employing heterocycles a new benzofuran metathesis was observed. Since most building blocks exhibit a technical importance the scalability will be addressed as well.

Dehydrogenative anodic cross-coupling of aryls: Sustainable, disruptive and scalable

256th National Meeting (2018)

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