The natural product UK-2A is the precursor of the picolinamide fungicide fenpicoxamid and also the inspiration for the design of macrolides with more desirable molecule attributes. Replacement of one of the macrocyclic esters in UK-2A with an ether linkage revealed a molecule with enhanced whole plant translation of its <i>in vitro</i> activity. Further modifications of the macrocyclic ring via systematic assembly of key synthetic inputs resulted in analogs with a broad spectrum of whole plant activity against agriculturally important pathogens. The synthetic assembly of these molecules and their bioefficacy will be the subject of this presentation.

Modular approach to macrocyclic fungicides

256th National Meeting (2018)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.