The manufacturing impurity profiles of crop protection active ingredients are specified as part of the registration process of the active substance. Some active ingredients contain relevant impurities that are of toxicological or ecotoxicological/environmental concern. European Union regulations require that if a relevant impurity is observed and declared on the specification, then a method must be available to analyze for this impurity within commercial formulated products relative to its concentration in the active substance. With potential low concentrations (ppb range) of these relevant impurities in formulated products that have complex matrices, it can create significant challenges for analytical method development. The development of various relevant impurity methods and the challenges encountered will be discussed.

Method development for relevant impurities in agricultural formulated products

256th National Meeting (2018)

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