<br/>The application of UCNPs for tissue imaging results in the introduction of rear earth elements (REEs) into human body, which may exert regulatory function in biological response. The different chemical and physical properties render REEs with different fate and toxicity in the body. We investigated the cytotoxicity REE NPs composed with different types of REEs. We found that the injury of cellular membrane led to the release of cathepsins from lysosomes outside, which then disrupted the normal structures of proteins and led to the detrimental effect on the survival of macrophages. In the current study, upon intravenous injection, we found that REE nanomaterials predominantly accumulated in liver, spleen and lungs. Our results suggested the significant different biological effects induced by altered REs in nanomaterials. Taken together, our investigation suggested that the regulatory role of UCNPs in neutrophils might be provoked by the composing element in UCNPs but not the other elements. It is important for the regulatory function of REEs in nanomaterials, which should be considered for UCNP designing. This detailed investigation of signaling pathways driving REE NP-induced toxicity to macrophages is essential for better understanding of their potential health risks to humans and the environment.<br/>

Toxicity of rare earth element containing nanomaterials

256th National Meeting (2018)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.