There is an ongoing discussion regarding proposed changes to the general International Estimate of Short-Term Intake (IESTI) equation used by many regulatory bodies including the specific IESTI version used by Joint Meeting on Pesticide Residues (JMPR). The IESTI equation provides an estimate of acute dietary exposure to pesticides based on 97.5th percentile large portion consumption data and is used to support the establishment of MRL values (the maximum legally allowed residue on food or feed). The IESTI equation is a deterministic model where both the food consumption and the residue concentration are represented by a single numerical value. The current IESTI output is known to be conservative, but its relationship to real world exposure has not been systematically explored. A benchmarking exercise was proposed at the 49th Codex Committee on Pesticide Residues (CCPR) meeting to compare current and proposed IESTI outcomes to probabilistic distributions of actual dietary exposures based on dietary monitoring data to assess real world exposures. This talk provides perspective on the progress of international discussions around IESTI occurring this year.

IESTI update: How a review of dietary exposure methodologies can best support global MRLs

256th National Meeting (2018)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.