To improve drug-like properties and introduce the novel vectors to access new design space, the design of new pharmaceutically relevant molecules with the increased sp3 characters presents the interesting challenges to synthetic organic chemistry. Herein we presented our efforts in collaboration with the Bull group at the Imperial College London to develop new synthetic methods to the facile access novel 3,3-disubstituted oxetanes and other related rings. These methods have been applied towards the synthesis of complex molecules with drug-like properties whose physicochemical properties have been studied to determine their feasibility as ketone, amide, and thioester isosteres.<br/>

Exploration of strained saturated heterocycles as isosteres in medicinal chemistry

256th National Meeting (2018)

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