Sulfonyl fluorides have become increasing important as alternatives to sulfonyl chlorides due to their better stability and selective reactivity. However, this in turn leads to slower reactivity and harsher conditions, for example, to make sulfonamides from sulfonyl chlorides. In this regard, we have developed a lewis acid – calcium triflimide mediated activation of sulfonyl fluorides to make sulfonamides. Both alkyl and aryl sulfonyl fluorides reacted with alkyl and aryl amines to make sulfonamides in good to excellent yields.

Lewis acid activation of sulfonyl fluorides to form sulfonamides

256th National Meeting (2018)

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