Chiral Lewis acids are powerful, mild catalysts for asymmetric transformations. Sepcifically, recent developments have shown that lanthanide-based Lewis acids facilitate a variety of highly enantioselective transformations. We herein report the development of an enantiodivergent strategy relying on chiral lanthanide triflates as catalysts. This method is applicable in organic synthesis as demonstrated in the preparation of both enantiomers of (+) and (-)-lingzhiol, a recently isolated meroterpenoid natural product.

Chiral lanthanide triflates enable enantiodivergent asymmetric transformations

256th National Meeting (2018)

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