Siderophores (Greek: iron carrier) are biosynthesized by bacteria and fungi for ferric ion uptake through chelation in iron deficient environments. These organisms require iron as an essential element in variety of their cellular pathways. It has been proved that brominated analogues of enterobactin, a well-studied siderophore, exhibit antibacterial property. Another siderophore, called azotochelin is also a catechol-based siderophore like enterobactin, and has potential to be an antibacterial lead. Our focus is to synthesize azotochelin analogues through structural modification, which will be potential antibacterial agents. We have synthesized a library of first generation analogues by modifying the aryl-ring component of this siderophore. This modification is expected to not interfere with iron binding. As the second phase, we will be studying the iron binding and antibacterial effect. Based on the results, we plan to synthesize a library of second generation analogues. Finally, we will test theses analogues for their iron-binding properties and antibacterial activity as well.

Design, synthesis and bioactivity testing of azotochelin analogs as potential antibiotics

256th National Meeting (2018)

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