In this presentation, we demonstrate a nature-inspired delivery system that explores assembling of nanocompartments/nanorecators upon external signal (magnetic field). The ingredients of the nanorecators are delivered by core-shell nanoparticles made of the magnetic core and block-copolymer brushes. The formation of the nanoreactor triggers biocatalytic reactions that results in release of the particle cargo. The specially designed stimuli-responsive biocatalytic system of superparamagnetic nanoparticles with a copolymer shell hosting the substrate and a complimentary enzyme is a powerful platform for remote control delivery and release of drugs and genetic materials. This delivery system combines the stimuli-triggered biocatalysis, remote control of biocatalysis and high selectivity of biocatalysis when only authorized biocatalytic reactions are triggered. The developed system provides an example of well-controlled magnetic field-triggered cancer drug release. The proposed platform is versatile and capable of delivery of various biological materials or therapeutic chemical molecules.

Remotely controlled assembly and biocatalytic release of cargo molecules

256th National Meeting (2018)

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