Inhibition of biofilm formation is one of the effective ways to combat the multidrug resistance. Marine natural products like Oroidin family containing 2-Aminoimidazole moiety has been shown to exhibit antibiofilm and antibacterial activity. In our research we have developed synthetic analogues of 2-aminoimidazole through formamidine chemistry. These molecules were further modified with different tails to evaluate whether they can enhance the antibiofilm activity. The molecule with best inhibition activities will be dimerized to check whether dimerization has a role in increasing the activity. SAR of the synthesized analogues will be presented.

Synthesis and evaluation for antibacterial and antibiofilm activities of 2-aminoimidazole derivatives

256th National Meeting (2018)

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