De novo protein design, in which one designs proteins beginning from first principles, provides an approach that critically tests our understanding of protein folding and function, while also laying the groundwork for the design of novel proteins and biomimetic polymers. The de novo design of proteins has proven to be a useful approach for understanding the features in a protein sequence that allow them to fold into their unique three-dimensional structures, as well as how their structures achieve complex functions from molecular recognition to catalysis. This talk will focus on the design of water-soluble and membrane proteins with predetermined structures and functions, including binding of metal ion cofactors, small molecule ligands, and the transmembrane domains of natural proteins.

<b>Award Address</b> (Arthur C. Cope Late Career Scholars Award sponsored by the Arthur C. Cope Fund). <i>De novo</i> protein design

256th National Meeting (2018)

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Award Address (Arthur C. Cope Late Career Scholars Award sponsored by the Arthur C. Cope Fund). De novo protein design