It is well-established that nanoparticle size has a great influence on the biological properties of particles, including those used in nanomedicine. Nanoparticle size determination is inherently complicated, as each technique measures a different aspect of size. For example, dynamic light scattering measures the average hydrodynamic diameter of a population of particles while atomic force microscopy measures the height of individual particles. This concept is well-illustrated by NIST’s gold nanoparticle reference materials, for which particle size was measured by six different techniques. Other metrological challenges specific to nanomedicine will be discussed.

Metrological challenges and issues related to measurement of nanoparticle size

256th National Meeting (2018)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.