This presentation will focus on recent particle sizing techniques used to support a request from the European Food Safety Administration for particle size characterization as they determine whether there is a potential for the presence of nanomaterials in a dietary supplement.  Regulatory guidance documents require Transmission Electron Microscopy and one additional sizing technique.  A brief discussion of why Atomic Force Microscopy was selected as the most appropriate metrological technique for this application will include meeting regulatory compliance needs as well as operational quality control laboratory demands such as cost and analysis time.  A summary of the development of the performance qualification of the methods, instruments, and software will be presented.  Finally, a summary of the data from the measurement of over 60,000 particles by TEM and over 3,000 particles by AFM will be presented, demonstrating a comprehensive understanding of the particle size distribution of the product.

Particle sizing of a food supplement in response to an EFSA request for characterization of potential nanomaterials

256th National Meeting (2018)

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