A combination of highly enantioselective enzyme methionine sulfoxide reductase A and an oxaziridine-type oxidant in a biphasic setup was utilized for deracemization of chiral sulfoxides. Remarkably, high enantiomeric excess was achieved with a wide range of substrates and thus provides a practical route for the synthesis of enantiopure sulfoxides.

Chemoenzymatic deracemization of chiral sulfoxides

256th National Meeting (2018)

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