Colloidal nanoparticles (NPs) may be valuable tools for in vivo diagnosis and therapy in the future. Before they can be safely using in clinics, their interaction with the human body needs to be understood for each individual particles. This involves for example biodistribution (concerning targeting) as well as toxicity (concerning safety). In order to avoid testing of each new NP formulation from scratch, ideally the biological response of any new NP could be predicted by the physicochemical properties of the NP. While there are many studies about the impact of certain physicochemical NP properties on the biological response of NPs, as for example size-, shape-, surface coating-dependence, a reliable prediction based on the physicochemical properties is not possible. In this presentation some ideas towards making better predictions will be presented.<br/>

Correlating the interaction of colloidal nanoparticles with biological matter with their physicochemical properties

256th National Meeting (2018)

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