We have developed a set of powerful new nano tools, which include photostable single plasmonic nanoparticle imaging probes, single molecule nanoparticle optical biosensors (SMNOBS), and far-field photostable-optical-nanoscopy (PHOTON). We have demonstrated that these new nano tools can overcome the drawbacks (e.g., photobleaching, photoblinking) of fluorescence-based probes and imaging methods for dynamics and quantitative single molecule imaging of single live cells with superior temporal and spatial resolutions over a desired long period of time. We have used these new nano tools to address several challenging biomedical questions including early cancer detection, multidrug resistance, signaling transduction pathways, and neuron-neuron communication. In this presentation, we will present these new nanobiotechnology and overview their applications, especially sensing and imaging of rare subsets of single cancer stem cells (CSCs) in human tissues <i>in situ</i>, aiming to develop new tools for early cancer detection and targeted therapy.

Photostable optical nanoscopy (PHOTON) for cancer research

256th National Meeting (2018)

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