Cryo-EM has been used extensively for the structure determination of proteins and RNA-protein complexes. However, it has yet to be proven that this technique can also be applied to the routine structure determination of free-standing large RNAs. This talk will focus on both experimental and computational hurdles for the application of cryo-EM to RNA structure determination.

Cryo-EM structure determination of large RNAs

256th National Meeting (2018)

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