We propose to encapsulate broad-spectrum antibiotics into pathogen-targeted polymeric nanoparticles to facilitate targeted drug delivery. Pathogen specific targeting is achieved by application of sugar-functionalized nanoparticles as drug carriers targeted for species-specific lectin binding. The <i>Pseudomonas aeruginosa</i> lectins, LecA and LecB, are two sugar-binding proteins distinct in structure, binding preference and involvement of biofilm formation in this pathogen. We will describe the presentation of LecA and LecB binding motifs on a series of polymeric nanoparticle cores and preliminary investigations of biological activity.<br/>

Targeted nanoparticles for pathogen-specific drug delivery

256th National Meeting (2018)

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