We present a strategy for packaging peptides as side-chains in high-density brush polymers as responsive, or proteolytically resistant materials. For this globular protein-like polymer (PLP) formulation, therapeutic peptides were shown to resist proteolytic degradation, enter cells efficiently and maintain biological function. In this presentation we describe the behavior of this class of peptide-polymer conjugate in the development of responsive materials for associating and entering diseased tissues and cells in vitro and in vivo. We will describe a general synthetic strategy for preparing globular like single polymer particles, and more traditional micellar particles capable of peptide, protein and small molecule delivery to cells and tissues.

Protein-like polymers as peptide, small molecule and protein delivery agents to cells and tissues

256th National Meeting (2018)

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