Bis (3- (trimethoxysilyl) propyl) amine: “P1” is an organofunctional silane polymer post hydrolysis that has been found to catalyze the one-pot reaction of alkynes producing high yields of α, α, dibromoketones alongside high regioselectivity within our lab. A unique feature of organosilanes is that the silanol groups can readily condense with each other to form polymeric structures that contain very stable siloxane bonds, in this case being very stable within aqueous solutions due to internal hydrogen bonding.  The organosilane P1 has also been found to exhibit properties as a green-catalyst that is both reusable meanwhile maintaining favorable conversion rates of desired product.  It has also been proposed that the sol-gel P1 acts a reaction vessel that contains a mode of directly initiating halogenation.  To our satisfaction, our method of di-halogenation has extended to both terminal and internal alkynes, as well as aliphatic compounds and compounds that vary in both steric and inductive effects with much success.  Currently our manuscript is pending for journal acceptance.  Our ambitions are now focused on the expansion of catalyst scope implemented as well as the further optimization of regioselectivity.<br/>

A recyclable sol-gel catalyzed approach: Efficient one pot synthesis of α,α di-halogenated hetones

256th National Meeting (2018)

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