Nanotechnology provides new innovative solutions for original as well as generic applications in a wide variety of industries including pharmaceuticals, agrochemicals, cosmetics, foods, nutraceuticals and home care. This technology has led to the creation of nano-formulated drugs, which have unique supramolecular structures with improved clinical utility such as increased exposure, reduced or eliminated food effect, changed administration route. The novel supramolecular structures can deliver substantial improvements in material properties and biological performances, such as: 1. Solution like behaviour that ensures optimal systemic exposure; 2. Substantial increase in apparent solubility facilitating the compound availability of absorption; 3. Unique absorption mechanism that does not require traditional dissolution processes and results in improved drug absorption. Using novel bottom-up nanoparticle pharmaceutical delivery technology, called SpeedyNano™, that relies on controlled continuous-flow precipitation, we have prepared several unique nanostructured pharma delivery systems. The properties of the produced nanostructured particles could be modified during the process by the precise control and optimization of various reaction parameters (e.g. temperature, flow rate, pH and concentration). Using examples of nano-formulating indomethacin, rosuvastatin, and zanamivir, as well as antibiotics we will demonstrate in this presentation how we could substantially improve their biological activities.

Development of novel nanostructured pharmaceuticals to enhance solubility and overall biological performance

256th National Meeting (2018)

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