5-Aminooxan-3-ols are useful building blocks in designing kinase inhibitors. We developed a novel route to synthesize 5-aminooxan-3-ol hydrochloride, from commercial available oxane-3,5-dione. Our method has a number of attractive features, including mild reaction conditions, good yield and easy purification [<b>Figure1</b>]. The ketone group of key intermediate <b>4</b> can be readily converted into other functional groups, such as nitrile, ester and fluoride, allowing more opportunities.

Novel synthetic method for 5-aminooxan-3-ol hydrochloride

256th National Meeting (2018)

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