The majority of Chemical Warfare Agents (CWAs) are organophosphorus based compounds which inhibit the enzyme acetylcholinesterase. CWAs disrupt the typical functioning of the nervous system and a lethal dose can quickly lead to respiratory failure and death. Due to the inherent toxicity of CWAs, we use simulant molecules to closely mimic their reactivity thus enabling us to screen their degradation using a range of catalysts. Metal Organic Frameworks (MOFs) are showing great promise as heterogeneous catalysts for CWA degradation. One such class of material are MOFs with zirconate clusters. We have identified a simple microwave-assisted method of activating these MOFs and thus enhancing their catalytic capabilities. The catalytic activity of the activated MOFs and their non-activated counterparts was investigated through catalytic screening reactions on simulants along with real CWAs. By comparing the degradation rates, we were able to identify a simulant system which closely resembles the degradation of CWAs. Finally, we report the hydrolysis of neat (no solvent, no buffer) V-series agent, VX, in the presence of our catalysts.

Zirconium MOF hydrates: Remediating organophosphorus contaminants

256th National Meeting (2018)

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