Registration of crop protection chemicals requires a detailed risk assessment of the compound under consideration towards the environmental as well as mammalian exposure targets. In order to understand the risk associated with a product, not only the parent compound, but all significant degradation products need to be identified and their toxicological significance established. A meaningful risk assessment therefore, requites identification of the metabolites/degradation products in a variety of environmental and animal studies which are conducted for the registration purposes. These studies often require the use of isotopic labelling of the test substances in a strategic manner, so that potentially toxic molecules generated as a result of the product use may be identified.  Some of the strategies employed in various registrations will be discussed.

Strategies for labelling test substances for regulatory studies

256th National Meeting (2018)

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