The structural-functional regulation of enzymes and drug-delivery agent by the administration of an external stimulus such as light could create photo-switches that exhibit unique biotechnological applications. Herein we demonstrate that molecular recognition of a novel photochromic ligand dihydroindolizine (DHI) by serine protease α-chymotrypsin (CHT) leads to the photo-control of enzymatic activity. Moreover, the photoinduced isomerization of DHI encapsulated in liposome leads to potential light-controlled drug delivery vehicles for potential anti-cancer effects.

Bioconjugate materials of photochromic dihydroindolizine for biomedical applications

256th National Meeting (2018)

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