Liposomal nanoparticles are essential in the delivery of chemotherapeutic drugs. The development of an ideal liposomal nanoparticle drug delivery system is of increasing interest to ensure that the conjugated drug carrier complex arrives and acts preferentially at the tumor site with high efficacy and lower toxicity. The focus of this work lies in the synthesis of functionalized liposomal nanoparticles with the biopolymer chitosan (CS) to enhance the stability nanoparticle dispersion.Characterization of the liposome vehicles were studied using Fourier Transform Infrared Spectroscopy (FTIR), zeta potential analysis, particle size analysis (PSA), and scanning electron microcopy (SEM). Preliminary findings in the characterization of the synthesized liposomes using FTIR showed characteristic bands at 3429 cm-1 due to -OH and -NH groups in chitosan and 1656 cm-1 amide band C-O stretching, along with N-H deformation. Structural characteristics of the synthesized liposomes were also studied by dynamic light scattering. The liposome suspensions presented exhibited mean diameters between 150 nm and 250 nm, polydispersity indexes (PDI) around 0.4, zeta potential values between -40 mV and -30 mV, indicating complex formation between the anionic liposomes and cationic chitosan molecules. The surface morphology of the nanovesicles were studied using scanning electron microscopy and it was observed that the liposomes are uniform in diameter (~190nm) with unilamelar structures. XRD analysis exhibited diffraction peaks corresponding to chitosan functionalization occurring at 20°2 theta. Stability studies of the functionalized CS-liposomes showed increased stability to aggregation versus pristine liposomes when stored at ambient temperatures.

Biopolymer functionalized liposomes for enhanced disperison stability of nanovesicles

256th National Meeting (2018)

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