The development of a stimuli-controlled drug delivery system for breast cancer was investigated using a nanoparticle peptide system which releases mock drug cargo in the presence of Cathepsin B. Current cancer therapies attack fast-growing healthy cells such as skin, hair, intestines, and bone marrow.1 The purpose of this research is to develop a system that releases drugs only in the presence of Cathepsin B to ensure that only carcinoma cells are targeted. Overexpression of Cathepsin B is correlated with invasive and metastatic phenotypes in cancer which corresponds to the studies that have been shown using Cathepsin B.2 From a literature search, 63 amino acids were found and analyzed to determine Cathepsin B cleavable peptide sequences.3,4,5 A consensus sequence of the highest occurring amino acids at the cleavage site was determined and position P1 was changed to the next highest occurring amino acid to generate additional sequences for analysis. Solid phase peptide synthesis was utilized to create a library of peptide sequences which were attached to a gold nanoparticle. The system will be analyzed in the presence of Cathepsin B in order to determine their affinity for the release of free chemotherapeutic drugs.

Cathepsin B stimuli controlled drug delivery system

2019 Spring National Meeting

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