The Parham cyclization methodolgy utilized to prepare isoquinolin-4(3H)-ones and tetrahydro-1H-benzo[d]azepin-1-ones from alkyl-N-(2-bromobenzyl)-N-(arylsulfonyl)amino acid esters and alkyl-N-(2-bromophenylethyl)-N-(arylsulfonyl)amino acid esters will be discussed.

Scope and limitation on the preparation of isoquinolin-4(3H)-ones and tetrahydro-1H-benzo[d]azepin-1-ones via Parham cyclization chemistry

2019 Spring National Meeting

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