Bielschowskysin is a furanocembranoid-derived natural product isolated from the gorgonian coral Pseudopterogorgia kallos. Due to its complex hexacyclic structure and potency against two cancer cell lines, bielschowskysin has drawn significant interest from the synthetic community. This compound is thought to be biosynthetically derived from bipinnatin J through key oxidations at the C7 and C8 positions, dearomatization of the furan ring, and a [2+2] cycloaddition. This work aims to prepare 13-acetoxy bipinnatin J (5), a furanocembranoid that could be used to biomimetically access bielschowskysin.

Toward a macrocyclic precursor of bielschowskysin

2019 Spring National Meeting

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