This lecture will describe our latest studies employing catalysts for the selective alteration of the complex glycopeptides antiobiotics and related carbohydrates.  In particular, catalysts that emerged from both combinatorial screening, as well as rational design will be presented.  In the latter case, we will detail our efforts to co-opt molecular mechanisms of biological activity for the orthogonal goal of chemical derivatization of the structure.  In addition to showing our results for various classes of bond forming reactions, we will present mechanistic studies that support some of the aspects of our original hypotheses.  Opportunities and challenges for fully aqueous glycosylations will also be presented.

Studies toward catalytic site-selective alterations of glycopeptide antibiotics and other carbohydrates

2019 Spring National Meeting

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