2-methoxy-4-prop-2-enylphenol, commonly known asEugenol, is a major chemical constituent of cloves. It is known to possess excellent antioxidant, antimicrobial and anesthetic activities. If consumed in excess, it forms a toxic quinone methide intermediate. Its toxicity is due to the oxidant and electrophilic behavior which causes oxidative stress and damages biological systems in the human body (Monks, T J, and D C Jones <i>et al</i>.). The objective of this study is to identify an alternate ester derivative of eugenol that possibly can not form quinone methide, while maintaining its beneficial properties. We synthesized various ester derivatives of eugenol using Fisher esterification method and tested their antioxidant activity using DPPH scavenging method. Fluorinated ester derivatives of eugenol showed comparable antioxidant activity properties to that of Eugenol.<br/>Dose dependent studies of one of the Fluorinated compounds showed higher antioxidant activity than that of Eugenol at 0.001M concentration.

Antioxidant activity of eugenol derivatives

2019 Spring National Meeting

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