Infectious diseases continue to be a threat to millions globally – largely because of highly effective immune evasion mechanisms employed by pathogens. Vaccines constitute one of the most effective tools to prevent disease. For numerous important diseases, however, currently available vaccines do not provide broad, durable, and effective protection. For instance, in several cases, immunodominant regions of protein immunogens are highly variable in sequence and elicit narrow or even strain-specific immune responses. To tackle this problem, we have been engineering antigens to elicit broadly protective antibodies. We will first discuss a “nanopatterning” based approach using green fluorescent protein (GFP) as a model immunogen. We will also discuss applications of the approach to design vaccines for clinically relevant infectious diseases such as Influenza, Malaria, and Zika, among others.

Designing vaccines that elicit broadly neutralizing antibodies

2019 Spring National Meeting

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