Lipoquinones are essential to the electron transport chain and the survival of many organisms. These lipoquinones are used by organisms to transport electrons and protons through the membrane by cycling through the membrane within the electron transport chain. There is much known about lipoquinones and of these lipoquinones, menaquinone is commonly found within many species. Although menaquinone is common, there is little literature on how MKs interact with lipids that comprise their environment, and this study aims to determine the interactions between menaquinone and two phospholipids. Compression isotherm experiments of mixed and pure Langmuir monolayers containing both phospholipid (dipalmitoylphosphatidylcholine, DPPC,  or dipalmitoylphosphatidylethanolamine, DPPE) and different molar fractions of MKs of varying tail length (MK-1 through MK-4) were conducted to see if the same effects were observed. It was found that MKs interact with phospholipids in a similar manner to as other quinones despite the difference in the headgroup between MK and the other lipoquinones.

Investigating interactions of short-chain menaquinones in Langmuir monolayers

2019 Spring National Meeting

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.