Parameters in metal-catalyzed oxidation reactions such as solvent, ligand, and oxidant have a dramatic impact on catalytic activity. A solvent may serve as a ligand in several intermediates or off-cycle pathways, and a ligand can have a dramatic impact on catalytic stability and selectivity. One example of this is in platinum-catalyzed C<sub>sp3</sub>–H oxidation reactions, wherein the role of water and specific oxidants are essential for catalytic activity. Herein we report an investigation into these parameters in an effort to enable a wide variety of functionalizations via general reaction conditions.<br/>

Role of solvent, ligand, and oxidant in reactivity and selectivity in platinum-catalyzed C–H functionalization

2019 Spring National Meeting

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.