Interest in research of mesoporous silica nanoparticles (MSN) is growing due its biomedical applications, drug delivery capabilities, pore sizes and surface characteristics. In this research, we report the synthesis and characterization of colloidal MSN and MSN crystals with drug delivery capabilities. The particles were characterized by performing FT - IR spectroscopy, Scanning Electron Microscopy (SEM), Diffracted Light Scattering (DLS) and Uv-Vis spectroscopy. In addition, drug encapsulation and loading capacity were studied by the addition of curcumin solutions at two different concentrations and three different volumes (small, medium and large quantities). Results shows that encapsulation of values for medium volumes varies from a 10% at two hours to a maximum encapsulation of 98 % at 48 hours. A comparison of small, medium and large volumes were evaluated at 12 hours and 24 hours. The results show a 63%, 30%, 41% encapsulation at 12 hours and 100%, 68 %, 66% at 24 hours respectively. The IR bands shows a successful encapsulation of the curcumin by the silica crystals. More studies will be performed to evaluate others drugs encapsulation and drug release capabilities.

Mesoporous silica nanoparticles (MSN) as a delivery system of anti-cancer drugs: A comparative study of synthesis and drug loading

2019 Spring National Meeting

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