Triazoles have been researched for their medicinal properties as a drug scaffold for the development of antimicrobial and antiviral agents. Imidazolium and benzimidazolium salt compounds have been extensively utilized due to their promising biological activities. However, the non-water soluble nature of these two classes of compounds has substantially decreased their viability in the clinical atmosphere. A preliminary structure activity relationship (SAR) study of a substituted class of compounds has corroborated the claim that triazole rings would provide the greatest water solubility. To further the understanding of triazolium salts as antimicrobial and antiviral agents, we present a SAR study of N,N’-bis-substituted triazolium salts synthesized from 1,2,3- and 1,2,4-triazole rings. The SAR study of triazolium salts will explore the variation of antimicrobial and antiviral activities of substituents on 1,2,3-triazole and 1,2,4-triazole rings.

Synthesis and biological activity of N,N’-bis-substituted-triazolium salts as potential anti-viral and antimicrobial agents

2019 Spring National Meeting

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