Fluorinated pyridines are highly tailorable molecules, being particularly susceptible to S<sub>N</sub>Ar reactions. The effect of a triazole substituent on the pyridines and the specific characteristics influencing nucleophilic substitution are described. Piperidine was used as a nucleophile in order to synthesize a potential p38α inhibitor. Fluorinated pyridines readily undergo nucleophilic substitution at the 4-position, but there is less known regarding reaction conditions for further substitution. It is shown that not only does nucleophilic aromatic substitution take place readily when the pyridine ring contains a triazole, but the substitution is selective and can therefore be applied more specifically to create novel compounds.

Substitution of fluorinated 1<i>H</i>-1,2,3-triazolopyridines by secondary amines

2019 Spring National Meeting

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Substitution of fluorinated 1H-1,2,3-triazolopyridines by secondary amines