Symmetrically trisubstituted compounds have been assembled into a potential drug library focused on pyridine and 1H-1,2,3 triazole moieties. Although they contain pyridine components, these heterocyclic compounds contain some features that differ from known synthetic drugs. Continuing this line of research, compounds featuring nitrogen-rich heterocycles and highly substituted aromatic rings were synthesized in acceptable yields using, among other techniques, copper (I) catalyzed azide-alkyne (CuAAC) “click” reactions, and confirmed with 1H NMR spectroscopy and elemental analysis. Compounds produced will be evaluated for biological viability as drug candidates, and/or further derivatization.

Synthesis of symmetrical trisubstituted 1H-1,2,3-triazolopyridines

2019 Spring National Meeting

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