Cellulose Nanofibrils (CNF) from wood are more and more investigated for their outstanding properties (high specific area, low density, excellent mechanical properties and chemical reactivity) besides their character of renewable resource and biocompatibility. The possibility to further expand the CNF use by tailoring their surface properties has been intensively explored in the last decade. Such fibrils of 5-20nm in width and 1-5µm long are able to form highly entangled networks which can entrap drugs.<br/>This paper reports several chemical modifications and adsorption of drug for monitoring their delivery and prolonged their release.<br/>A special focus onto ciprofloxacine containing membrane will be proposed by comparing grafting vs adsorption devices. Chemical characterization like FTIR, NMR, Elemental analysis have been performed to confirm or not the grafting. Drug release has been studied with UV following different procedures (in liquid, solid and on surface). Antimicrobial test have confirmed activity towards E.Coli and S.Aureus. Such results will be compared with another molecule release, i.e. the digluconate chlorhexidine, which tend to adsorb to cellulose nanofibrils surface. A comparison between tempo oxidized and classic CNF will be performed. The presence of cyclodextrine will also be proposed and their influence onto drug release will be discussed. All the release has been successfully prolonged compared to classic gauze in both case and confirms the role of nanocellulose membrane as an efficient medical device for drug release.<br/>

Cellulose nanofibrils from wood for drug molecule immobilization and release

2019 Spring National Meeting

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.