3,5-Disubstituted isoxazoles were prepared through cycloaddition of organic nitrile oxides and alkynes in one-pot syntheses. After purifying the isoxazole products using recrystallization in ethanol, the isoxazole derivatives were reduced using hydrogenation and the results compared to those from using the reduction method using iron powder catalyst in hexafluoro-2-propanol. Products of the reactions were purified using recrystallization and characterized using spectroscopic methods.

Reduction of isoxazole derivatives via catalytic hydrogenation compared to reduction using iron powder catalyst

2019 Spring National Meeting

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